Organic lead salts
Selleck Chemical LLC Magnesium lactate trihydrate S4829-25mg
Magnesium lactate the magnesium salt of lactic acid is a mineral supplement that is added to some food and beverages as an acidity regulator
Apexbio Technology LLC Peramivir Trihydrate 1041434-82-5 10mg
Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination
Selleck Chemical LLC Scopolamine HBr trihydrate
Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55 3 nM
Apexbio Technology LLC VO-Ohpic trihydrate 476310-60-8 25mg
VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research
Medchemexpress LLC RNase L-IN-1 trihydrochloride | 98.1% | 542.67 g/mol | C27H35FN6O3S | 10 MG
RNase L-IN-1 trihydrochloride is the trihydrochloride salt form of a small-molecule inhibitor of RNase L, supplied for research use to study RNase L-mediated RNA degradation, antiviral responses, and inflammation. The compound is provided as a solid salt suitable for biochemical and cellular assays.
- Inhibits RNase L activity for mechanistic and antiviral research.
- Trihydrochloride salt form improves solubility and handling.
- High purity (~98.1%) suitable for research applications.
- Yellow to brown solid appearance, powder form for storage.
- Molecular formula C27H35FN6O3S; molecular weight 542.67 g/mol.
- Store powder at -20°C for long-term stability; follow supplier guidelines.
Medchemexpress LLC VO-Ohpic (trihydrate) | 476310-60-8 | 98.0% | 1 ML
VO-Ohpic (trihydrate) is a highly potent inhibitor of PTEN, with an IC50 of 46±10 nM. It has a molecular weight of 415.20 and a chemical formula of C12H16N2O11V. This compound appears as a solid, ranging in color from light green to green.
- Significantly inhibits PTEN activity at low nanomolar concentrations (IC50, 46±10 nM).
- Demonstrates inhibition constants Kic and Kiu of 27±6 nM and 45±11 nM, respectively.
- Acts as a specific and potent PTEN inhibitor.
- Inhibits PTEN in mice via intra-peritoneal injection (10 μg/kg) 30 minutes before ischemia.
- Significantly decreases myocardial infarct size in treated mice.
Medchemexpress LLC VO-Ohpic (trihydrate) | 476310-60-8 | 98.0% | 25 MG
VO-Ohpic trihydrate is a highly potent inhibitor of PTEN, with an IC50 of 46±10 nM. It significantly inhibits PTEN activity at low nanomolar concentrations. It is described as an encouragingly specific and potent PTEN inhibitor, and the most potent inhibitor (IC50=35 nM) of PTEN lipid phosphatase activity.
- Highly potent PTEN inhibitor
- IC50 of 46±10 nM for PTEN
- Molecular weight: 415.20
- Formula: C12H16N2O11V
- Appearance: Solid, light green to green
- Soluble in DMSO (≥ 50 mg/mL); insoluble in H2O
- Useful for in vitro inhibition studies and in vivo applications in mice
Selleck Chemical LLC Peramivir Trihydrate S2716-5mg
Peramivir Trihydrate (BCX-1812 RWJ-270201 S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent specific influenza viral neuraminidase inhibitor with an IC50 of median 0 09 nM
Medchemexpress LLC Tanuxiciclib trihydrochloride | 1983984-11-7 | ≥98.0% | 588.94 g/mol | C26H28Cl3N5O3 | 5 MG
Tanuxiciclib trihydrochloride is the trihydrochloride salt of tanuxiciclib, a cyclin-dependent kinase (CDK) inhibitor supplied as a research-grade solid for biochemical and cell-based studies of CDK signaling and cell-cycle regulation. The compound is provided with high chemical purity and is intended for laboratory research applications only.
Medchemexpress LLC Vevorisertib trihydrochloride | 1416775-08-0 | 99.13% | 696.11 | 25 MG
Vevorisertib trihydrochloride is a selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitor. It potently inhibits phosphorylation of AKT with Kd values of 1.2 nM for AKT1 and 8.6 nM for AKT1-E17K, and IC50 values of 0.55, 0.81, and 1.3 nM for AKT1, AKT2, and AKT3, respectively. This compound can be used for cancer research.
- Selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitor
- Potently inhibits phosphorylation of AKT
- Used for cancer research
Apexbio Technology LLC Peramivir Trihydrate 1041434-82-5 50mg
Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination
Apexbio Technology LLC VO-Ohpic trihydrate 476310-60-8 10mg
VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research
Selleck Chemical LLC Irinotecan HCl Trihydrate S2217-100mg
Irinotecan HCl Trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar Campto CPT-11) which is a topoisomerase I inhibitor with IC50 of 15 8 and 5 17 M for LoVo cells and HT-29 cells respectively
Medchemexpress LLC VO-Ohpic trihydrate | 476310-60-8 | 98.0% | 200 MG
VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC50 of 46±10 nM. It is a sterically demanding molecule that significantly inhibits PTEN activity in low nanomolar concentrations. It is considered an encouragingly specific and potent PTEN inhibitor and is the most potent inhibitor (IC50=35 nM) of the PTEN lipid phosphatase activity.
- Potent PTEN inhibitor
- IC50 of 46±10 nM
- Significantly inhibits PTEN activity in low nanomolar concentrations
- Considered specific and potent
- Most potent inhibitor of PTEN lipid phosphatase activity
- Used in research
Apexbio Technology LLC Irinotecan HCl Trihydrate(Synonyms: Campto, Camptosar, CPT-11, Irinotecan hydrochloride trihydrate, Irinotecan hydrochloride, Irinotecan HCl, Irinotecan, CPT 11 hydrochloride trihydrate), 10mM (in 1mL DMSO), CAS: 136572-09-3.
Irinotecan HCl Trihydrate (CAS 136572-09-3) also known as CPT-11 is a semisynthetic derivative of camptothecin designed to improve therapeutic efficacy while reducing toxicity It acts as a soluble prodrug which undergoes enzymatic cleavage by carboxylesterases in vivo to yield SN-38 a potent inhibitor of topoisomerase I CPT-11 exhibits cytotoxicity against leukemia (P388) cell lines with an IC50 of 3 4 M and demonstrates antitumor activity in vitro and in vivo against both drug-sensitive and multidrug-resistant tumor models It is FDA-approved for treating metastatic colorectal cancer following progression after fluorouracil-based therapies